Research Papers

53 peer-reviewed publications and counting

100+ collaborators across 10+ institutions

A chronological list of our laboratory publications, spanning multi-modal imaging, computational imaging research, AI model development, Bayesian statistical modeling, and clinical applications in retinal diseases.

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2026

Hou J, von der Emde L, Mukherjee S, Vance E, de Silva Tharindu, Shen LL, Keenan TDL. Improving Efficiency in Geographic Atrophy Clinical Trial Design: Run-In Phases and Single-Arm Trials. JAMA Ophthalmology. 2026.
Mukherjee S, Chew E, Keenan TDL, Lu Z, Sherif N, Arunachalam T, Duic C, Prasad M, Siddig F, Saroya J, Chahal N, Taha AT, Yiu G, Shen LL, Stewart JM, Cukras C, De Silva T. Simultaneous Segmentation of Geographic Atrophy in Longitudinally Acquired Fundus Autofluorescence Images. Ophthalmology Science. 2026;6(4):101110.

2025

Shen LL, Stewart JM, Cole MA, Mackenzie ME, Brodie F. Novel Syringe Attachment for One-Handed Anterior Chamber Paracentesis. BMC Ophthalmology. 2025.
Vo A, Shen LL*, Pak I, Taha AT, Diaz AZ, Stewart JM. Association Between Baseline Subfoveal Choroidal Thickness and Anatomical and Functional Outcomes in Geographic Atrophy. Ophthalmology Science. 2025.
Shen LL, Applegate CA, Rubin GS, Sunness JS. Patient-reported Visual Difficulties Associated with Geographic Atrophy from Age-related Macular Degeneration. International Ophthalmology. 2025;45(1):412.
Warren JL, Prunas O, Shen LL. Studying the long-term natural history of diseases using a shape-restricted nonparametric temporal realignment method. Annals of Applied Statistics. 2025.
Shen LL, Zhang Y, Wong J, Foote KG, Porco TC, Wang RK, Roorda A, Duncan JL. Longitudinal Assessment of Cone Structure, Choriocapillaris, and Retinal Sensitivity in Choroideremia. Investigative Ophthalmology & Visual Science. 2025;66(11):40.
Shen LL, Kaiser PK, Liu J, Stewart JM, Heyang M, Keenan TDL, Sunness JS, Rosenfeld PJ, Chew EY, Del Priore LV. Determinants of Four-Year Visual Acuity Loss in Geographic Atrophy – An Analysis of AREDS and AREDS2. Ophthalmology. 2025;132(7):785-798.
Shen LL, Bhisitkul A, Lewis GM, Borirakchanyavat S, Bhisitkul RB. Proliferative Retinopathy in Nail-Patella Syndrome. American Journal of Ophthalmology Case Reports. 2025; 38:102320.
Taha AT, Shen LL*, Diaz A, Chahal N, Saroya J, Sun M, Allingham MJ, Farsiu S, Yiu G, Keenan J, Stewart JM. Association of Hyperautofluorescence Signals with Geographic Atrophy Progression in the METforMIN Trial. Ophthalmology Science. 2025;5(1):100620.

2024

Lad EM, Fleckenstein M, Holz FG, Shen L, Del Priore LV, Silva R, Staurenghi G, Waheed N, Chakravarthy U. Informing Endpoints for Clinical Trials of Geographic Atrophy. Annual Review of Vision Science. 2024 Sep; 10(1): 455-476.
Heyang M, Warren JL, Ocieczek P, Duncan JL, Moosajee M, Del Priore LV, Shen LL. Long-term Natural History of Ellipsoid Zone Width in USH2A-Retinopathy. British Journal of Ophthalmology. 2024;109(3):383-390.
Zhang C, Kahan E, Begaj T, Friedman SM, Deobhakta A, Heyang M, Shen LL, Moshfeghi D, Wai K, Parikh R. Geographic Atrophy Natural History Versus Treatment: Time to Fovea. Ophthalmic Surgery, Lasers and Imaging Retina. 2024;55(10):576-585.
Shen LL, Keenan JD, Chahal N, Taha AT, Saroya J, Ma CJ, Sun M, Yang D, Psaras C, Callander J, Flaxel C, Fawzi A, Schlesinger TK, Wong RW, Leung LSB, Eaton AM, Steinle NC, Telander DG, Afshar AR, Neuwelt MD, Lim JI, Yiu GC, Stewart JM. METformin FOR the MINimization of Geographic Atrophy Progression (METforMIN) – A Randomized Trial. Ophthalmology Science. 2024;4(3):100440.
Michalak SM, Mangalesh S, Chen Y, Shen LL, Tai V, Winter KP, Sarin N, Ying G, Toth CA, Vajzovic L. Longitudinal Choroidal Development in Preterm Infants. Ophthalmology Science. 2024;4(1):100359.

2023

Young BK, Zhao PY, Shen LL, Fahim A, Jayasundera T. Local Progression Kinetics of Macular Atrophy in Recessive Stargardt Disease. Ophthalmic Genetics. 2023;44(6):539-546.
Ahluwalia A, Shen LL, Bao Y, Sun M, Young BK, Park MM, Del Priore LV. The influence of the topographic location of geographic atrophy on vision-related quality of life in nonexudative age-related macular degeneration. Graefe's Archive for Clinical and Experimental Ophthalmology. 2023;261(3):699-708.
Shen LL, Mangalesh S, McGeehan B, Seely K, Tai V, Sarin N, Finkle J, Winter KP, Tran-Viet D, Benner EJ, Freedman SF, El-Dairi MA, Ying G, Toth CA. Biphasic Change in Retinal Nerve Fibre Layer Thickness from 30 to 60 Weeks Postmenstrual Age in Preterm Infants. British Journal of Ophthalmology. 2023;107(11):1680–1686.

2022

Seely K, Mangalesh S, Shen LL, McGeehan B, Ying G, Sarin N, Vajzovic L, Prakalapakorn S, Freedman S, Toth CA. Association Between Retinal Microanatomy in Preterm Infants and Their 9-Month Visual Acuity. JAMA Ophthalmology. 2022;140(7):699-706.
Shen LL, Del Priore LV, Warren JL. A Hierarchical Bayesian Entry Time Realignment Method to Study the Long-Term Natural History of Diseases. Scientific Reports. 2022;12(1):4869.
Young BK, Shen LL, Del Priore LV. Subretinal Drusenoid Deposit Formation: Insights from Turing Patterns. Translational vision science & technology. 2022;11(3):5.
Shen LL, Sun M, Ahluwalia A, Park M, Young BK, Lad EM, Toth CA, Del Priore LV. Natural history of central sparing in geographic atrophy secondary to non-exudative age-related macular degeneration. British Journal of Ophthalmology. 2022;106(5):689-695.

2021

Shen LL, Sun M, Ahluwalia A, Park MM, Young BK, Del Priore LV. Local Progression Kinetics of Geographic Atrophy Depends Upon the Border Location. Investigative Ophthalmology & Visual Science. 2021;62(13):28.
Park M, Young BK, Shen LL, Adelman R, Del Priore LV. Topographic Variation of Retinal Vascular Density in Normal Eyes Using Optical Coherence Tomography Angiography. Translational Vision Science & Technology. 2021;10(12):15.
Shen LL, Xie Y, Sun M, Ahluwalia A, Park M, Young BK, Del Priore LV. Associations of systemic health and medication use with the enlargement rate of geographic atrophy in age-related macular degeneration. British Journal of Ophthalmology. 2023 Feb;107(2):261-266.
Shen LL, Mangalesh S, Michalak SM, McGeehan B, Sarin N, Finkle J, Winter KP, Tran-Viet D, Benner EJ, Vajzovic L, Freedman SF, Younge N, Cotten CM, El-Dairi MA, Ying G, Toth CA. Associations between systemic health and retinal nerve fibre layer thickness in preterm infants at 36 weeks postmenstrual age. British Journal of Ophthalmology. 2023;107(2):242-247.
Young BK, Shen LL, Del Priore LV. An in silica model for RPE loss patterns in choroideremia. Investigative Ophthalmology & Visual Science. 2021;62(14):10.
Michalak SM, Mangalesh S, Shen LL, McGeehan B, Winter KP, Sarin N, Finkle J, Cotton M, Ying G, Toth CA, Vajzovic L. Systemic factors associated with a thinner choroid in preterm infants. Ophthalmology Science. 2021;1(2):100032.
Ahluwalia A, Shen LL, Chen EM, Park M, Young BK, Del Priore LV. Geographic atrophy severity and mortality in age-related macular degeneration. Graefe’s Archive for Clinical and Experimental Ophthalmology. 2021;259(9):2643-2651.
Shen LL, Sun M, Ahluwalia A, Young BK, Park M, Del Priore LV. Geographic atrophy growth is strongly related to lesion perimeter: unifying effects of lesion area, number, and circularity on growth. Ophthalmology Retina. 2021;5(9):868-878.
Shen LL, Sun M, Ahluwalia A, Young BK, Park M, Toth CA, Lad EM, Del Priore LV. Relationship of topographic distribution of geographic atrophy to visual acuity in nonexudative age-related macular degeneration. Ophthalmology Retina. 2021;5(8):761-774.
Shen LL, Mangalesh S, McGeehan B, Tai V, Sarin N, El-Dairi MA, Freedman SF, Maguire M, Toth CA. Birth weight is a significant predictor of retinal nerve fiber layer thickness at 36 weeks postmenstrual age in preterm infants. American Journal of Ophthalmology. 2021;222:41-53.
Ahluwalia A, Shen LL, Del Priore LV. Central geographic atrophy vs. neovascular age-related macular degeneration: differences in longitudinal vision-related quality of life. Graefe’s Archive for Clinical and Experimental Ophthalmology. 2021;259(2):307-316.
Shen LL, Ahluwalia A, Sun M, Young BK, Grossetta Nardini H, Del Priore LV. Long-term natural history of visual acuity in eyes with choroideremia: a systematic review and meta-analysis of data from 1004 individual eyes. British Journal of Ophthalmology. 2021;105(2):271-278.

2020

Shen LL, Sun M, Grossetta Nardini H, Del Priore LV. Progression of unifocal vs. multifocal geographic atrophy in age-related macular degeneration: a systematic review and meta-analysis. Ophthalmology Retina. 2020;4(9):899-910.
Shen LL, Ahluwalia A, Sun M, Young BK, Grossetta Nardini H, Del Priore LV. Long-term natural history of atrophy in eyes with choroideremia: a systematic review and meta-analysis of individual-level data. Ophthalmology Retina. 2020;4(8):840-852.
Shen LL, Sun M, Khetpal S, Grossetta Nardini H, Del Priore LV. Topographic variation of the growth rate of geographic atrophy in nonexudative age-related macular degeneration: a systematic review and meta-analysis. Investigative Ophthalmology & Visual Science. 2020;61(1):2.

2019

Shen LL, Sun M, Grossetta Nardini H, Del Priore LV. Natural history of autosomal recessive Stargardt disease in untreated eyes: a systematic review and meta-analysis of study- and individual-level data. Ophthalmology. 2019;126(9):1288-1296.
Shen LL, Qi W, Duarte J, Nagar A, Merchant NB. Acute renal and splenic infarctions as the initial manifestations of atrial fibrillation. The Lancet. 2019;393(10183):1856.
Shen LL, Liu F, Grossetta Nardini H, Del Priore LV. Reclassification of fundus autofluorescence patterns surrounding geographic atrophy based on progression rate: a systematic review and meta-analysis. Retina. 2019;39(10):1829-1839.
Shen LL, Liu F, Nardini HG, Del Priore LV. Fellow eye status is a biomarker for the progression rate of geographic atrophy: a systematic review and meta-analysis. Ophthalmology Retina. 2019;3(4):305-315.

2018

Shen L, Liu F, Nardini HG, Del Priore LV. Natural history of geographic atrophy in untreated eyes with nonexudative age-related macular degeneration: a systematic review and meta-analysis. Ophthalmology Retina. 2018;2(9):914-921.